6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress effector T cell responses and can reduce the efficacy of cancer immunotherapies. We previously showed that ultra-small polymer nanoparticles efficiently drain to the lymphatics after intra...

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Detalles Bibliográficos
Autores principales: Jeanbart, Laura, Kourtis, Iraklis C., van der Vlies, André J., Swartz, Melody A., Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506469/
https://www.ncbi.nlm.nih.gov/pubmed/25982370
http://dx.doi.org/10.1007/s00262-015-1702-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506469/
https://www.ncbi.nlm.nih.gov/pubmed/25982370
http://dx.doi.org/10.1007/s00262-015-1702-8

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