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Protein conformational plasticity and complex ligand-binding kinetics explored by atomistic simulations and Markov models
Understanding the structural mechanisms of protein–ligand binding and their dependence on protein sequence and conformation is of fundamental importance for biomedical research. Here we investigate the interplay of conformational change and ligand-binding kinetics for the serine protease Trypsin and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Pub. Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506540/ https://www.ncbi.nlm.nih.gov/pubmed/26134632 http://dx.doi.org/10.1038/ncomms8653 |