Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

The proteasome is a highly regulated protease complex fundamental for cell homeostasis and controlled cell cycle progression. It functions by removing a wide range of specifically tagged proteins, including key cellular regulators. Here we present the structure of the human 20S proteasome core bound...

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Detalles Bibliográficos
Autores principales: da Fonseca, Paula C.A., Morris, Edward P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506541/
https://www.ncbi.nlm.nih.gov/pubmed/26133119
http://dx.doi.org/10.1038/ncomms8573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506541/
https://www.ncbi.nlm.nih.gov/pubmed/26133119
http://dx.doi.org/10.1038/ncomms8573

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