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Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain**
Peptide ligases expand the repertoire of genetically encoded protein architectures by synthesizing new peptide bonds, energetically driven by ATP or NTPs. Here, we report the discovery of a genuine ligase activity in human legumain (AEP) which has important roles in immunity and tumor progression th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506564/ https://www.ncbi.nlm.nih.gov/pubmed/25630877 http://dx.doi.org/10.1002/anie.201409135 |