A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

BACKGROUND: Tumor lymphangiogenesis plays an important role in promoting growth and metastasis of tumors, but no antilymphangiogenic agent is used clinically. Based on the effect of norcantharidin (NCTD) on lymphangiogenesis of human lymphatic endothelial cells (LECs), we firstly investigated the an...

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Detalles Bibliográficos
Autores principales: Li, Xin-Ping, Jing, Wei, Sun, Jian-Jun, Liu, Zhong-Yan, Zhang, Jing-Tao, Sun, Wei, Zhu, Wei, Fan, Yue-Zu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506614/
https://www.ncbi.nlm.nih.gov/pubmed/26187792
http://dx.doi.org/10.1186/s12885-015-1521-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506614/
https://www.ncbi.nlm.nih.gov/pubmed/26187792
http://dx.doi.org/10.1186/s12885-015-1521-5

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