Cargando…

A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

BACKGROUND: Tumor lymphangiogenesis plays an important role in promoting growth and metastasis of tumors, but no antilymphangiogenic agent is used clinically. Based on the effect of norcantharidin (NCTD) on lymphangiogenesis of human lymphatic endothelial cells (LECs), we firstly investigated the an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xin-Ping, Jing, Wei, Sun, Jian-Jun, Liu, Zhong-Yan, Zhang, Jing-Tao, Sun, Wei, Zhu, Wei, Fan, Yue-Zu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506614/ https://www.ncbi.nlm.nih.gov/pubmed/26187792 http://dx.doi.org/10.1186/s12885-015-1521-5

Ejemplares similares

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
por: Pan, Mu-Su, et al.
Publicado: (2020)

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway
por: Yu, Jinlong, et al.
Publicado: (2014)

Matrix metalloproteinase 14 participates in corneal lymphangiogenesis through the VEGF-C/VEGFR-3 signaling pathway
por: Du, Hai-Tao, et al.
Publicado: (2016)

BANCR positively regulates the HIF-1α/VEGF-C/VEGFR-3 pathway in a hypoxic microenvironment to promote lymphangiogenesis in pancreatic cancer cells
por: Hao, Shaolong, et al.
Publicado: (2022)

Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization
por: Zhang, Ying, et al.
Publicado: (2021)

Preparation and characterization of norcantharidin liposomes modified with stearyl glycyrrhetinate
por: Zhu, Jing, et al.
Publicado: (2018)

Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway
por: Zheng, Jie, et al.
Publicado: (2014)

Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling
por: Ochsenbein, Alexandra M., et al.
Publicado: (2016)

Enhancement of cardiac lymphangiogenesis by transplantation of CD34(+)VEGFR-3(+) endothelial progenitor cells and sustained release of VEGF-C
por: Zhang, Hai-feng, et al.
Publicado: (2019)

VEGF‐C/VEGFR‐3 axis protects against pressure‐overload induced cardiac dysfunction through regulation of lymphangiogenesis
por: Lin, Qiu‐Yue, et al.
Publicado: (2021)

3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish
por: Okuda, Kazuhide S., et al.
Publicado: (2021)

Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling
por: Da, Wei, et al.
Publicado: (2019)

Norcantharidin Inhibits Renal Interstitial Fibrosis by Blocking the Tubular Epithelial-Mesenchymal Transition
por: Li, Ying, et al.
Publicado: (2013)

Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
por: Chen, Yu-Jen, et al.
Publicado: (2012)

Targeting VEGF/VEGFR to Modulate Antitumor Immunity
por: Yang, Ju, et al.
Publicado: (2018)

ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m(6)A modification to improve wound healing of diabetic foot ulcers
por: Zhou, Jie, et al.
Publicado: (2021)

Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis
por: Sha, Meng, et al.
Publicado: (2018)

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation
por: Huggenberger, Reto, et al.
Publicado: (2010)

Inhibition of Tumor Vasculogenic Mimicry and Prolongation of Host Survival in Highly Aggressive Gallbladder Cancers by Norcantharidin via Blocking the Ephrin Type a Receptor 2/Focal Adhesion Kinase/Paxillin Signaling Pathway
por: Wang, Hui, et al.
Publicado: (2014)

Correction: Norcantharidin Inhibits Renal Interstitial Fibrosis by Blocking the Tubular Epithelial-Mesenchymal Transition
por: Li, Ying, et al.
Publicado: (2013)

Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling
por: Qin, Tingting, et al.
Publicado: (2020)

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
por: Tang, Jiabu, et al.
Publicado: (2017)

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation
por: Huang, Xionggao, et al.
Publicado: (2017)

Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment
por: Liu, Guihong, et al.
Publicado: (2021)

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
por: Durré, Tania, et al.
Publicado: (2018)

Roles of the TGF-β–VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis
por: Kinashi, Hiroshi, et al.
Publicado: (2018)

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3
por: Alishekevitz, Dror, et al.
Publicado: (2016)

Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells
por: Yang, Yazong, et al.
Publicado: (2016)

ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis
por: Liu, Po-I, et al.
Publicado: (2023)

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
por: Chen, Wei-Sheng, et al.
Publicado: (2016)

Review targeted drug delivery systems for norcantharidin in cancer therapy
por: Zhai, Bing-Tao, et al.
Publicado: (2022)

VEGF-VEGFR Signals in Health and Disease
por: Shibuya, Masabumi
Publicado: (2014)

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis
por: Yan, Huiwen, et al.
Publicado: (2017)

Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
por: Liu, Qian, et al.
Publicado: (2022)

Erratum: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
por: Chen, Wei-Sheng, et al.
Publicado: (2016)

Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer
por: Dziobek, Konrad, et al.
Publicado: (2019)

Non-target effects on soil microbial parameters of the synthetic pesticide carbendazim with the biopesticides cantharidin and norcantharidin
por: Shao, Hainan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6302h442cs28ckvumormjhpf29