Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation

Keap1 protein acts as a cellular sensor for oxidative stresses and regulates the transcription level of antioxidant genes through the ubiquitination of a corresponding transcription factor, Nrf2. A small molecule capable of binding to the Nrf2 interaction site of Keap1 could be a useful medicine. He...

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Detalles Bibliográficos
Autores principales: Satoh, Mikiya, Saburi, Hajime, Tanaka, Tomoyuki, Matsuura, Yoshinori, Naitow, Hisashi, Shimozono, Rieko, Yamamoto, Naoyoshi, Inoue, Hideki, Nakamura, Noriko, Yoshizawa, Yoshitaka, Aoki, Takumi, Tanimura, Ryuji, Kunishima, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506958/
https://www.ncbi.nlm.nih.gov/pubmed/26199865
http://dx.doi.org/10.1016/j.fob.2015.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506958/
https://www.ncbi.nlm.nih.gov/pubmed/26199865
http://dx.doi.org/10.1016/j.fob.2015.06.011

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