Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

The frequency of chromosome segregation errors during meiosis I (MI) in oocytes increases with age. The two-hit model suggests that errors are caused by the combination of a first hit that creates susceptible crossover configurations and a second hit comprising an age-related reduction in chromosome...

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Detalles Bibliográficos
Autores principales: Sakakibara, Yogo, Hashimoto, Shu, Nakaoka, Yoshiharu, Kouznetsova, Anna, Höög, Christer, Kitajima, Tomoya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507009/
https://www.ncbi.nlm.nih.gov/pubmed/26130582
http://dx.doi.org/10.1038/ncomms8550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507009/
https://www.ncbi.nlm.nih.gov/pubmed/26130582
http://dx.doi.org/10.1038/ncomms8550

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