Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation

Toll-like receptor 4 (TLR4) plays an important role in innate immunity by eliciting inflammation. Upon receptor engagement, transforming growth factor β-activated kinase 1 (TAK1) is an essential mediator that transmits a signal from the receptor to downstream effectors, IκB kinase (IKK) and the mito...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, I-Ting, Hsu, Pang-Hung, Hsu, Wan-Ching, Chen, Nien-Jung, Tseng, Ping-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507259/
https://www.ncbi.nlm.nih.gov/pubmed/26189595
http://dx.doi.org/10.1038/srep12300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507259/
https://www.ncbi.nlm.nih.gov/pubmed/26189595
http://dx.doi.org/10.1038/srep12300

Ejemplares similares