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Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation

Toll-like receptor 4 (TLR4) plays an important role in innate immunity by eliciting inflammation. Upon receptor engagement, transforming growth factor β-activated kinase 1 (TAK1) is an essential mediator that transmits a signal from the receptor to downstream effectors, IκB kinase (IKK) and the mito...

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Detalles Bibliográficos
Autores principales:	Chen, I-Ting, Hsu, Pang-Hung, Hsu, Wan-Ching, Chen, Nien-Jung, Tseng, Ping-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507259/ https://www.ncbi.nlm.nih.gov/pubmed/26189595 http://dx.doi.org/10.1038/srep12300

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