Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability

Spinal muscular atrophy (SMA) presents severe muscle weakness with limited motor neuron (MN) loss at an early stage, suggesting potential functional alterations in MNs that contribute to SMA symptom presentation. Using SMA induced pluripotent stem cells (iPSCs), we found that SMA MNs displayed hyper...

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Detalles Bibliográficos
Autores principales: Liu, Huisheng, Lu, Jianfeng, Chen, Hong, Du, Zhongwei, Li, Xue-Jun, Zhang, Su-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507262/
https://www.ncbi.nlm.nih.gov/pubmed/26190808
http://dx.doi.org/10.1038/srep12189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507262/
https://www.ncbi.nlm.nih.gov/pubmed/26190808
http://dx.doi.org/10.1038/srep12189

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