Cargando…

PDGFRβ signaling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (VSMCs). However, the direct effects of PDGF receptor β (PDGFRβ) activation on VSMCs have not been studied in the context of atherosclerosis. Here, we present a new mouse model of atherosclerosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Chaoyong, Medley, Shayna C., Hu, Taishan, Hinsdale, Myron E., Lupu, Florea, Virmani, Renu, Olson, Lorin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507293/ https://www.ncbi.nlm.nih.gov/pubmed/26183159 http://dx.doi.org/10.1038/ncomms8770

Ejemplares similares

STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ
por: He, Chaoyong, et al.
Publicado: (2017)

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis
por: Buhl, Eva M, et al.
Publicado: (2020)

New insights into the role of iron in inflammation and atherosclerosis
por: Cornelissen, Anne, et al.
Publicado: (2019)

Hypercholesterolemia Tunes Hematopoietic Stem/Progenitor Cells for Inflammation and Atherosclerosis
por: Ma, Xiaojuan, et al.
Publicado: (2016)

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
por: Iwayama, Tomoaki, et al.
Publicado: (2015)

Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia
por: Sharifi, Mahtab, et al.
Publicado: (2017)

Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing
por: Yao, Longbiao, et al.
Publicado: (2022)

Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia
por: Zech, Loren A, et al.
Publicado: (2008)

Atherosclerosis severity in patients with familial hypercholesterolemia: The role of T and B lymphocytes
por: Fonzar, Waleria T., et al.
Publicado: (2022)

Familial hypercholesterolemia supravalvular aortic stenosis and extensive atherosclerosis
por: Prajapati, Rajpal, et al.
Publicado: (2018)

Effects of castration on atherosclerosis in Yucatan minipigs with genetic hypercholesterolemia
por: Shim, Jeong T., et al.
Publicado: (2020)

Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms
por: Newman, Alexandra AC, et al.
Publicado: (2021)

The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II): - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis -
por: Shiomi, Masashi
Publicado: (2020)

Nuclear Transport Modulation Reduces Hypercholesterolemia, Atherosclerosis, and Fatty Liver
por: Liu, Yan, et al.
Publicado: (2013)

Spatial Metabolomics Reveals Localized Impact of Influenza Virus Infection on the Lung Tissue Metabolome
por: Dean, Danya A., et al.
Publicado: (2022)

The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis
por: Lupu, Florea, et al.
Publicado: (2020)

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells
por: Wu, Erxi, et al.
Publicado: (2008)

Synergistic Effects of Inflammation and Atherogenic Dyslipidemia on Subclinical Carotid Atherosclerosis Assessed by Ultrasound in Patients with Familial Hypercholesterolemia and Their Family Members
por: Lin, Po-Chih, et al.
Publicado: (2022)

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
por: Davis, Bryan T., et al.
Publicado: (2014)

Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia
por: Hamamdzic, Damir, et al.
Publicado: (2013)

SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia
por: Liu, Ming-Ming, et al.
Publicado: (2022)

Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study
por: Pérez de Isla, Leopoldo, et al.
Publicado: (2023)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

High-Sensitivity C-Reactive Protein and Carotid Intima Media Thickness as Markers of Subclinical Inflammation and Atherosclerosis in Pediatric Patients with Hypercholesterolemia
por: Blinc, Lana, et al.
Publicado: (2020)

PDGFR‐β and kidney fibrosis
por: Ortiz, Alberto
Publicado: (2020)

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
por: Chi, Sum Shing, et al.
Publicado: (2010)

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023)

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis
por: Sozen, Erdi, et al.
Publicado: (2014)

PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis
por: Momtazi-Borojeni, Amir Abbas, et al.
Publicado: (2021)

Local intravascular delivery of low-density-lipoprotein cholesterol corresponds with increased intimal thickening in a healthy porcine coronary model. A prelude to development of a model of atherosclerosis
por: Buszman, Piotr P., et al.
Publicado: (2019)

Genetic basis of hypercholesterolemia in adults
por: Saadatagah, Seyedmohammad, et al.
Publicado: (2021)

Is PDGFR an important target for E-3810?
por: Damia, Giovanna, et al.
Publicado: (2012)

Genomics of PDGFR-rearranged hypereosinophilic syndrome
por: Rheinbay, Esther, et al.
Publicado: (2023)

ARF sees Pdgfrβ through the miR
por: Reed, Sara M, et al.
Publicado: (2014)

Dysbiosis and inflammation in periodontitis: synergism and implications for treatment
por: Hajishengallis, George
Publicado: (2017)

Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis
por: Busso, Dolores, et al.
Publicado: (2014)

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia
por: Miyajima, Chiharu, et al.
Publicado: (2018)

Bitter Melon (Momordica charantia L.) Supplementation Has No Effect on Hypercholesterolemia and Atherosclerosis in Mice
por: Mohammadmoradi, Shayan, et al.
Publicado: (2020)

“Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia
por: Podgórski, Michał, et al.
Publicado: (2020)

Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia
por: Xu, Yitong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vkbpme2ur5arnorbd8hluoegi3