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Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL

STUDY QUESTION: Does inhibition of dimethylarginine dimethylaminohydrolase (DDAH) increase the sensitivity of trophoblasts to TRAIL-induced apoptosis? SUMMARY ANSWER: Inhibition of DDAH1, but not DDAH2, increases the sensitivity of trophoblasts to TRAIL-induced apoptosis. WHAT IS KNOWN ALREADY: Succ...

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Detalles Bibliográficos
Autores principales: Lumicisi, B.A., Cartwright, J.E., Leslie, K., Wallace, A.E., Whitley, G.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507332/
https://www.ncbi.nlm.nih.gov/pubmed/26082478
http://dx.doi.org/10.1093/humrep/dev138