Cancer-associated TERT promoter mutations abrogate telomerase silencing

Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established. We used genome editing of human pluripotent stem cells with physiological telomerase expression to el...

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Detalles Bibliográficos
Autores principales: Chiba, Kunitoshi, Johnson, Joshua Z, Vogan, Jacob M, Wagner, Tina, Boyle, John M, Hockemeyer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507476/
https://www.ncbi.nlm.nih.gov/pubmed/26194807
http://dx.doi.org/10.7554/eLife.07918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507476/
https://www.ncbi.nlm.nih.gov/pubmed/26194807
http://dx.doi.org/10.7554/eLife.07918

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