Therapy-induced tumour secretomes promote resistance and tumour progression

Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with BRAF, ALK, or EGFR kinase inhibitors induces a complex network of secreted signals in drug-stressed melanoma and lung adenocarcinoma cells....

Descripción completa

Detalles Bibliográficos
Autores principales: Obenauf, Anna C., Zou, Yilong, Ji, Andrew L., Vanharanta, Sakari, Shu, Weiping, Shi, Hubing, Kong, Xiangju, Bosenberg, Marcus C., Wiesner, Thomas, Rosen, Neal, Lo, Roger S., Massagué, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507807/
https://www.ncbi.nlm.nih.gov/pubmed/25807485
http://dx.doi.org/10.1038/nature14336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507807/
https://www.ncbi.nlm.nih.gov/pubmed/25807485
http://dx.doi.org/10.1038/nature14336

Ejemplares similares