Therapeutic Implications of Activation of the Host Gene (Dleu2) Promoter for miR-15a/16-1 in Chronic Lymphocytic Leukemia (CLL)

Genetic lesions and other regulatory events lead to silencing of the 13q14 locus in a majority of chronic lymphocytic leukemia (CLL) patients. This locus encodes a pair of critical pro-apoptotic microRNAs, miR-15a/16-1. Decreased levels of miR-15a/16-1 are critical for the increased survival exhibit...

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Detalles Bibliográficos
Autores principales: Kasar, S, Underbayev, C, Yuan, Y, Hanlon, M, Aly, S, Chang, V, Batish, M, Gavrilova, T, Badiane, F, Degheidy, H, Marti, G, Raveche, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508006/
https://www.ncbi.nlm.nih.gov/pubmed/23995789
http://dx.doi.org/10.1038/onc.2013.291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508006/
https://www.ncbi.nlm.nih.gov/pubmed/23995789
http://dx.doi.org/10.1038/onc.2013.291

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