Cargando…
Structural Basis for the Inhibition of a Phospholipase A(2)-Like Toxin by Caffeic and Aristolochic Acids
One of the main challenges in toxicology today is to develop therapeutic alternatives for the treatment of snake venom injuries that are not efficiently neutralized by conventional serum therapy. Venom phospholipases A(2) (PLA(2)s) and PLA(2)-like proteins play a fundamental role in skeletal muscle...
Autores principales: | Fernandes, Carlos A. H., Cardoso, Fábio Florença, Cavalcante, Walter G. L., Soares, Andreimar M., Dal-Pai, Maeli, Gallacci, Marcia, Fontes, Marcos R. M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508052/ https://www.ncbi.nlm.nih.gov/pubmed/26192963 http://dx.doi.org/10.1371/journal.pone.0133370 |
Ejemplares similares
-
Structural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA(2) Inhibition
por: dos Santos, Juliana I., et al.
Publicado: (2011) -
Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A(2)-like proteins using functional, structural and bioinformatics approaches
por: Salvador, Guilherme H. M., et al.
Publicado: (2019) -
Structural and Phylogenetic Studies with MjTX-I Reveal a Multi-Oligomeric Toxin – a Novel Feature in Lys49-PLA(2)s Protein Class
por: Salvador, Guilherme H. M., et al.
Publicado: (2013) -
Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties
por: Oliveira, Cláudia S., et al.
Publicado: (2018) -
Structural basis for phospholipase A(2)-like toxin inhibition by the synthetic compound Varespladib (LY315920)
por: Salvador, Guilherme H. M., et al.
Publicado: (2019)