Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

DYRK1A is a pleiotropic protein kinase with diverse functions in cellular regulation, including cell cycle control, neuronal differentiation, and synaptic transmission. Enhanced activity and overexpression of DYRK1A have been linked to altered brain development and function in Down syndrome and neur...

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Detalles Bibliográficos
Autores principales: Rüben, Katharina, Wurzlbauer, Anne, Walte, Agnes, Sippl, Wolfgang, Bracher, Franz, Becker, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508061/
https://www.ncbi.nlm.nih.gov/pubmed/26192590
http://dx.doi.org/10.1371/journal.pone.0132453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508061/
https://www.ncbi.nlm.nih.gov/pubmed/26192590
http://dx.doi.org/10.1371/journal.pone.0132453

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