RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response

BACKGROUND: The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are hypersensitive to proteotoxic stress....

Descripción completa

Detalles Bibliográficos
Autores principales: Meijering, Roelien A. M., Wiersma, Marit, van Marion, Denise M. S., Zhang, Deli, Hoogstra-Berends, Femke, Dijkhuis, Anne-Jan, Schmidt, Martina, Wieland, Thomas, Kampinga, Harm H., Henning, Robert H., Brundel, Bianca J. J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508109/
https://www.ncbi.nlm.nih.gov/pubmed/26193369
http://dx.doi.org/10.1371/journal.pone.0133553

Ejemplares similares

Ejemplares similares