p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy

Here we report that focal adhesion kinase (FAK) is required for optimal signalling to the Akt-p70S6K-S6 pathway in squamous cell carcinoma (SCC) cells. Specifically, in SCCs that are genetically deficient for FAK, there is reduced phosphorylation of Akt, p70S6K and S6, and signalling to Akt-p70S6K-S...

Descripción completa

Detalles Bibliográficos
Autores principales: Sandilands, Emma, Schoenherr, Christina, Frame, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508348/
https://www.ncbi.nlm.nih.gov/pubmed/26071201
http://dx.doi.org/10.1016/j.cellsig.2015.05.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508348/
https://www.ncbi.nlm.nih.gov/pubmed/26071201
http://dx.doi.org/10.1016/j.cellsig.2015.05.017

Ejemplares similares