Cargando…

Divergent roles of BECN1 in LC3 lipidation and autophagosomal function

BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells. Despite its significant role in a number of cellular and physiological processes, the exact function of BECN1 in autophagy remains controversi...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Ruina, Peng, Jingyu, Yuan, Pengfei, Xu, Fang, Wei, Wensheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Basic Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509441/ https://www.ncbi.nlm.nih.gov/pubmed/25955014 http://dx.doi.org/10.1080/15548627.2015.1034404

Ejemplares similares

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy
por: Pedro, Jose Manuel Bravo-San, et al.
Publicado: (2015)

BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein
por: Liu, Juan, et al.
Publicado: (2017)

BECN1 is involved in the initiation of mitophagy: It facilitates PARK2 translocation to mitochondria
por: Choubey, Vinay, et al.
Publicado: (2014)

Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity
por: Takáts, Szabolcs, et al.
Publicado: (2015)

Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination
por: Xu, Congfeng, et al.
Publicado: (2015)

ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
por: Wang, Pei, et al.
Publicado: (2014)

TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1
por: Han, Tianyu, et al.
Publicado: (2018)

A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation
por: Wang, Jian-Da, et al.
Publicado: (2015)

Coronavirus NSP6 restricts autophagosome expansion
por: Cottam, Eleanor M, et al.
Publicado: (2014)

BORC coordinates encounter and fusion of lysosomes with autophagosomes
por: Jia, Rui, et al.
Publicado: (2017)

Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion
por: Brandstaetter, Hemma, et al.
Publicado: (2015)

Membrane dynamics of ATG4B and LC3 in autophagosome formation
por: Zhou, Yuanyuan, et al.
Publicado: (2021)

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival
por: Zhang, Fan, et al.
Publicado: (2014)

Nucleocytoplasmic Distribution and Dynamics of the Autophagosome Marker EGFP-LC3
por: Drake, Kimberly R., et al.
Publicado: (2010)

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis
por: Ge, Liang, et al.
Publicado: (2013)

Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest
por: He, Ruina, et al.
Publicado: (2017)

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure
por: Corcelle-Termeau, Elisabeth, et al.
Publicado: (2016)

MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals
por: Yuan, Jia, et al.
Publicado: (2015)

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C
por: Baeken, Marius W., et al.
Publicado: (2020)

Emerging roles of ATG proteins and membrane lipids in autophagosome formation
por: Nishimura, Taki, et al.
Publicado: (2020)

Rotavirus Increases Levels of Lipidated LC3 Supporting Accumulation of Infectious Progeny Virus without Inducing Autophagosome Formation
por: Arnoldi, Francesca, et al.
Publicado: (2014)

FGF7/KGF regulates autophagy in keratinocytes: A novel dual role in the induction of both assembly and turnover of autophagosomes
por: Belleudi, Francesca, et al.
Publicado: (2014)

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth
por: Feng, Xing, et al.
Publicado: (2019)

Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation
por: Moloughney, Joseph G., et al.
Publicado: (2011)

Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
por: Roberts, Rebecca, et al.
Publicado: (2013)

Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice
por: Mizunoe, Yuhei, et al.
Publicado: (2017)

LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014)

Autophagosomes contribute to intracellular lipid distribution in enterocytes
por: Khaldoun, Salem Ait, et al.
Publicado: (2014)

Chloroquine-Induced Accumulation of Autophagosomes and Lipids in the Endothelium
por: Bik, Ewelina, et al.
Publicado: (2021)

Rabies virus phosphoprotein P5 binding to BECN1 regulates self-replication by BECN1-mediated autophagy signaling pathway
por: Liu, Juan, et al.
Publicado: (2020)

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation
por: Hu, Xiaohua, et al.
Publicado: (2019)

TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
por: Wetzel, Lisa, et al.
Publicado: (2020)

TFG binds LC3C to regulate ULK1 localization and autophagosome formation
por: Carinci, Marianna, et al.
Publicado: (2021)

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection
por: Krause, Kathrin, et al.
Publicado: (2018)

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
por: Nguyen, Thanh Ngoc, et al.
Publicado: (2016)

Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation
por: Jacquin, Elise, et al.
Publicado: (2017)

Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells
por: Maheshwari, Chinmay, et al.
Publicado: (2022)

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
por: Maeda, Shintaro, et al.
Publicado: (2020)

Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines
por: Koukourakis, Michael I., et al.
Publicado: (2015)

ATG2 transports lipids to promote autophagosome biogenesis
por: Valverde, Diana P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a3caolovpj0ucopglco0h8cfsl