The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5(−/−) mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age. Despite greater food intake, Fmo5(−/−) mice weigh less...

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Detalles Bibliográficos
Autores principales: Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R., Shephard, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509511/
https://www.ncbi.nlm.nih.gov/pubmed/26049045
http://dx.doi.org/10.1016/j.bcp.2015.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509511/
https://www.ncbi.nlm.nih.gov/pubmed/26049045
http://dx.doi.org/10.1016/j.bcp.2015.05.013

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