AAV ANCESTRAL RECONSTRUCTION LIBRARY ENABLES SELECTION OF BROADLY INFECTIOUS VIRAL VARIANTS

Adeno-associated virus (AAV) vectors have achieved clinical efficacy in treating several diseases. Enhanced vectors are required to extend these landmark successes to other indications, however, and protein engineering approaches may provide the necessary vector improvements to address such unmet me...

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Detalles Bibliográficos
Autores principales: Santiago-Ortiz, Jorge, Ojala, David S., Westesson, Oscar, Weinstein, John R., Wong, Sophie Y., Steinsapir, Andrew, Kumar, Sanjay, Holmes, Ian, Schaffer, David V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509550/
https://www.ncbi.nlm.nih.gov/pubmed/26186661
http://dx.doi.org/10.1038/gt.2015.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509550/
https://www.ncbi.nlm.nih.gov/pubmed/26186661
http://dx.doi.org/10.1038/gt.2015.74

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