Reactive Oxygen Species and Mitochondrial DNA Damage and Repair in BCR-ABL1 Cells Resistant to Imatinib

Imatinib revolutionized the therapy of chronic myeloid leukemia (CML), but the resistance to it became an emerging problem. We reported previously that CML cells expressing the BCR/ABL1 fusion gene, accumulated a high level of reactive oxygen species (ROS) due to deregulated mitochondrial electron t...

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Detalles Bibliográficos
Autores principales: Blasiak, Janusz, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509616/
https://www.ncbi.nlm.nih.gov/pubmed/26309809
http://dx.doi.org/10.1089/biores.2015.0022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509616/
https://www.ncbi.nlm.nih.gov/pubmed/26309809
http://dx.doi.org/10.1089/biores.2015.0022

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