Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein

The human von Hippel-Lindau (VHL) tumor suppressor is a marginally stable protein previously used as a model substrate of eukaryotic refolding and degradation pathways. When expressed in the absence of its cofactors, VHL cannot fold and is quickly degraded by the quality control machinery of the cel...

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Detalles Bibliográficos
Autores principales: Brock, Kelly P., Abraham, Ayelet-chen, Amen, Triana, Kaganovich, Daniel, England, Jeremy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509718/
https://www.ncbi.nlm.nih.gov/pubmed/26027734
http://dx.doi.org/10.1016/j.str.2015.04.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509718/
https://www.ncbi.nlm.nih.gov/pubmed/26027734
http://dx.doi.org/10.1016/j.str.2015.04.015

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