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Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein
The human von Hippel-Lindau (VHL) tumor suppressor is a marginally stable protein previously used as a model substrate of eukaryotic refolding and degradation pathways. When expressed in the absence of its cofactors, VHL cannot fold and is quickly degraded by the quality control machinery of the cel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509718/ https://www.ncbi.nlm.nih.gov/pubmed/26027734 http://dx.doi.org/10.1016/j.str.2015.04.015 |