Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination

Imidazoleglycerol-phosphate dehydratase (IGPD) catalyzes the Mn(II)-dependent dehydration of imidazoleglycerol phosphate (IGP) to 3-(1H-imidazol-4-yl)-2-oxopropyl dihydrogen phosphate during biosynthesis of histidine. As part of a program of herbicide design, we have determined a series of high-reso...

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Detalles Bibliográficos
Autores principales: Bisson, Claudine, Britton, K. Linda, Sedelnikova, Svetlana E., Rodgers, H. Fiona, Eadsforth, Thomas C., Viner, Russell C., Hawkes, Tim R., Baker, Patrick J., Rice, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509728/
https://www.ncbi.nlm.nih.gov/pubmed/26095028
http://dx.doi.org/10.1016/j.str.2015.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509728/
https://www.ncbi.nlm.nih.gov/pubmed/26095028
http://dx.doi.org/10.1016/j.str.2015.05.012

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