Cargando…

Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination

Imidazoleglycerol-phosphate dehydratase (IGPD) catalyzes the Mn(II)-dependent dehydration of imidazoleglycerol phosphate (IGP) to 3-(1H-imidazol-4-yl)-2-oxopropyl dihydrogen phosphate during biosynthesis of histidine. As part of a program of herbicide design, we have determined a series of high-reso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bisson, Claudine, Britton, K. Linda, Sedelnikova, Svetlana E., Rodgers, H. Fiona, Eadsforth, Thomas C., Viner, Russell C., Hawkes, Tim R., Baker, Patrick J., Rice, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509728/ https://www.ncbi.nlm.nih.gov/pubmed/26095028 http://dx.doi.org/10.1016/j.str.2015.05.012

Ejemplares similares

Mirror‐Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide
por: Bisson, Claudine, et al.
Publicado: (2016)

Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials
por: Rice, Christopher A., et al.
Publicado: (2018)

“Mn-locking” effect by anionic coordination manipulation stabilizing Mn-rich phosphate cathodes
por: Zhang, Wei, et al.
Publicado: (2023)

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM
por: Rawson, Shaun, et al.
Publicado: (2018)

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup
por: Wichelecki, Daniel J., et al.
Publicado: (2014)

Molecular Evolution of Threonine Dehydratase in Bacteria
por: Yu, Xuefei, et al.
Publicado: (2013)

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2018)

Cloning, purification and preliminary crystallographic analysis of a conserved hypothetical protein, SA0961 (YlaN), from Staphylococcus aureus
por: Xu, Ling, et al.
Publicado: (2006)

The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases
por: Dillon, Shane C, et al.
Publicado: (2004)

(Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila)
por: Wilson, Jason S., et al.
Publicado: (2019)

The mechanism of a formaldehyde-sensing transcriptional regulator
por: Denby, Katie J., et al.
Publicado: (2016)

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase
por: Ratia, Kiira, et al.
Publicado: (2014)

The Role of ACT-Like Subdomain in Bacterial Threonine Dehydratases
por: Yu, Xuefei, et al.
Publicado: (2014)

Evolution of Enzymatic Activities in the Enolase Superfamily: Galactarate Dehydratase III from Agrobacterium tumefaciens C58
por: Groninger-Poe, Fiona P., et al.
Publicado: (2014)

LOCALIZATION OF POLYSOME-BOUND ALBUMIN AND SERINE DEHYDRATASE IN RAT LIVER CELL FRACTIONS
por: Ikehara, Yukio, et al.
Publicado: (1973)

Crystallization and X-ray diffraction analysis of an l-arabinonate dehydratase from Rhizobium leguminosarum bv. trifolii and a d-xylonate dehydratase from Caulobacter crescentus
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2016)

Liver δ-Aminolevulinate Dehydratase Activity is Inhibited by Neonicotinoids and Restored by Antioxidant Agents
por: Sauer, Elisa, et al.
Publicado: (2014)

δ-Aminolevulinic Acid Dehydratase Polymorphism and Risk of Brain Tumors in Adults
por: Rajaraman, Preetha, et al.
Publicado: (2005)

Dehydratase mediated 1-propanol production in metabolically engineered Escherichia coli
por: Jain, Rachit, et al.
Publicado: (2011)

Regulation of Delta-Aminolevulinic Acid Dehydratase by Krüppel-Like Factor 1
por: Desgardin, Aurelie D., et al.
Publicado: (2012)

Mutation of GDP-Mannose-4,6-Dehydratase in Colorectal Cancer Metastasis
por: Nakayama, Kotarosumitomo, et al.
Publicado: (2013)

Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis
por: Hahn, Frank, et al.
Publicado: (2014)

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone
por: Grzegorzewicz, Anna E., et al.
Publicado: (2014)

Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway
por: Liu, Chang, et al.
Publicado: (2015)

Identification of essential amino acid residues in the nisin dehydratase NisB
por: Khusainov, Rustem, et al.
Publicado: (2015)

Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
por: Barajas, Jesus F., et al.
Publicado: (2019)

New function of aldoxime dehydratase: Redox catalysis and the formation of an expected product
por: Yamada, Masatoshi, et al.
Publicado: (2017)

Diene Incorporation by a Dehydratase Domain Variant in Modular Polyketide Synthases
por: Hobson, Christian, et al.
Publicado: (2022)

A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan
por: Bäumgen, Marcus, et al.
Publicado: (2021)

Nucleotide sugar dehydratases: Structure, mechanism, substrate specificity, and application potential
por: Vogel, Ulrike, et al.
Publicado: (2022)

The role of oligomerization in the optimization of cyclohexadienyl dehydratase conformational dynamics and catalytic activity
por: East, Nicholas J., et al.
Publicado: (2022)

Identification of Polyketide Inhibitors Targeting 3-Dehydroquinate Dehydratase in the Shikimate Pathway of Enterococcus faecalis
por: Cheung, Vivian Wing Ngar, et al.
Publicado: (2014)

Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline?
por: Baierle, Marília, et al.
Publicado: (2014)

A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead.
por: Smith, C M, et al.
Publicado: (1995)

TssA from Burkholderia cenocepacia: expression, purification, crystallization and crystallographic analysis
por: Owen, Hayley J., et al.
Publicado: (2018)

Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.
por: Wetmur, J G
Publicado: (1994)

Correction: dehydratase mediated 1-propanol production in metabolically engineered Escherichia coli
por: Jain, Rachit, et al.
Publicado: (2012)

Classifying glycerol dehydratase by its functional residues and purifying selection in its evolution
por: Escobar, Andres Julian Gutierrez, et al.
Publicado: (2010)

Effects of δ‐aminolevulinic acid dehydratase silencing on the primary and secondary metabolisms of citrus
por: Killiny, Nabil, et al.
Publicado: (2018)

Downregulation of delta‐aminolevulinate dehydratase is associated with poor prognosis in patients with breast cancer
por: Ge, Jie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hadvngql81bcd1r72ldbf93jm0