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Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509784/ https://www.ncbi.nlm.nih.gov/pubmed/26046760 http://dx.doi.org/10.1016/j.stem.2015.05.002 |