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Splicing remodels the let-7 primary microRNA to facilitate Drosha processing in Caenorhabditis elegans

MicroRNAs (miRNAs) are a class of small noncoding RNAs that use partial base-pairing to recognize and regulate the expression of messenger RNAs (mRNAs). Mature miRNAs arise from longer primary transcripts (pri-miRNAs) that are processed to a shorter hairpin precursor miRNA (pre-miRNA) by the Micropr...

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Detalles Bibliográficos
Autores principales: Mondol, Vanessa, Ahn, Byoung Chan, Pasquinelli, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509930/
https://www.ncbi.nlm.nih.gov/pubmed/26081559
http://dx.doi.org/10.1261/rna.052118.115