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Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis

TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 autoregulates the abundance of its own transcript TARDBP by binding to an intron in the 3′ untranslat...

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Detalles Bibliográficos
Autores principales: D'Alton, Simon, Altshuler, Marcelle, Lewis, Jada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509932/
https://www.ncbi.nlm.nih.gov/pubmed/26089325
http://dx.doi.org/10.1261/rna.047647.114