Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Genome engineering technologies based on the CRISPR/Cas9 and TALE systems are enabling new approaches in science and biotechnology. However, the specificity of these tools in complex genomes and the role of chromatin structure in determining DNA binding are not well understood. We analyzed the genom...

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Detalles Bibliográficos
Autores principales: Polstein, Lauren R., Perez-Pinera, Pablo, Kocak, D. Dewran, Vockley, Christopher M., Bledsoe, Peggy, Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510000/
https://www.ncbi.nlm.nih.gov/pubmed/26025803
http://dx.doi.org/10.1101/gr.179044.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510000/
https://www.ncbi.nlm.nih.gov/pubmed/26025803
http://dx.doi.org/10.1101/gr.179044.114

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