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A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo
Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show that Notch signalling augments the response of neuroepithelial ce...
Autores principales: | Stasiulewicz, Magdalena, Gray, Shona D., Mastromina, Ioanna, Silva, Joana C., Björklund, Mia, Seymour, Philip A., Booth, David, Thompson, Calum, Green, Richard J., Hall, Emma A., Serup, Palle, Dale, J. Kim |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510595/ https://www.ncbi.nlm.nih.gov/pubmed/25995356 http://dx.doi.org/10.1242/dev.125237 |
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