MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3

Peripherally derived regulatory T (pT(reg)) cell generation requires T-cell receptor (TCR) signalling and the cytokines TGF-β1 and IL-2. Here we show that TCR signalling induces the microRNA miR-31, which negatively regulates pT(reg)-cell generation. miR-31 conditional deletion results in enhanced i...

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Detalles Bibliográficos
Autores principales: Zhang, Lingyun, Ke, Fang, Liu, Zhaoyuan, Bai, Jing, Liu, Jinlin, Yan, Sha, Xu, Zhenyao, Lou, Fangzhou, Wang, Hong, Zhu, Huiyuan, Sun, Yang, Cai, Wei, Gao, Yuanyuan, Li, Qun, Yu, Xue-Zhong, Qian, Youcun, Hua, Zichun, Deng, Jiong, Li, Qi-Jing, Wang, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510656/
https://www.ncbi.nlm.nih.gov/pubmed/26165721
http://dx.doi.org/10.1038/ncomms8639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510656/
https://www.ncbi.nlm.nih.gov/pubmed/26165721
http://dx.doi.org/10.1038/ncomms8639

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