Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts

AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Na(v)1.5 currents in homozygous RyR2-P2328S (RyR2(S/S)) mice wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Salvage, S C, King, J H, Chandrasekharan, K H, Jafferji, D I G, Guzadhur, L, Matthews, H R, Huang, C L-H, Fraser, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Cardiovascular Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510817/
https://www.ncbi.nlm.nih.gov/pubmed/25850710
http://dx.doi.org/10.1111/apha.12505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510817/
https://www.ncbi.nlm.nih.gov/pubmed/25850710
http://dx.doi.org/10.1111/apha.12505

Ejemplares similares