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Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts

AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Na(v)1.5 currents in homozygous RyR2-P2328S (RyR2(S/S)) mice wit...

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Detalles Bibliográficos
Autores principales:	Salvage, S C, King, J H, Chandrasekharan, K H, Jafferji, D I G, Guzadhur, L, Matthews, H R, Huang, C L-H, Fraser, J A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Cardiovascular Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510817/ https://www.ncbi.nlm.nih.gov/pubmed/25850710 http://dx.doi.org/10.1111/apha.12505

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