ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

Intracellular amyloid-β (Aβ) accumulation is a key feature of early Alzheimer's disease and precedes the appearance of Aβ in extracellular plaques. Aβ is generated through proteolytic processing of amyloid precursor protein (APP), but the intracellular site of Aβ production is unclear. APP has...

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Detalles Bibliográficos
Autores principales: Edgar, James R., Willén, Katarina, Gouras, Gunnar K., Futter, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510853/
https://www.ncbi.nlm.nih.gov/pubmed/26002056
http://dx.doi.org/10.1242/jcs.170233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510853/
https://www.ncbi.nlm.nih.gov/pubmed/26002056
http://dx.doi.org/10.1242/jcs.170233

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