Cargando…

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

Intracellular amyloid-β (Aβ) accumulation is a key feature of early Alzheimer's disease and precedes the appearance of Aβ in extracellular plaques. Aβ is generated through proteolytic processing of amyloid precursor protein (APP), but the intracellular site of Aβ production is unclear. APP has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edgar, James R., Willén, Katarina, Gouras, Gunnar K., Futter, Clare E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510853/ https://www.ncbi.nlm.nih.gov/pubmed/26002056 http://dx.doi.org/10.1242/jcs.170233

Ejemplares similares

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
por: Willén, Katarina, et al.
Publicado: (2017)

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
por: Willén, Katarina, et al.
Publicado: (2017)

Molecular Mechanism of Multivesicular Body Biogenesis by ESCRT Complexes
por: Wollert, Thomas, et al.
Publicado: (2010)

Multivesicular bodies: co-ordinated progression to maturity
por: Woodman, Philip G, et al.
Publicado: (2008)

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies
por: Hermey, Guido
Publicado: (2015)

Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer’s Disease
por: Kobro-Flatmoen, Asgeir, et al.
Publicado: (2023)

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
por: Bache, Kristi G., et al.
Publicado: (2003)

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress
por: Huttunen, Moona, et al.
Publicado: (2021)

Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation
por: Clarke, Aryel L., et al.
Publicado: (2022)

Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body
por: Tabernero, Lydia, et al.
Publicado: (2018)

Pharmacological targeting of the β-amyloid precursor protein intracellular domain
por: Branca, Caterina, et al.
Publicado: (2014)

Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains
por: Takahashi, Reisuke H., et al.
Publicado: (2021)

Extracellular vesicles: where the amyloid precursor protein carboxyl‐terminal fragments accumulate and amyloid‐β oligomerizes
por: Pérez‐González, Rocío, et al.
Publicado: (2020)

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies
por: Schroeder, Barbara, et al.
Publicado: (2012)

Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
por: Takahashi, Reisuke H., et al.
Publicado: (2013)

Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
por: Kobro-Flatmoen, Asgeir, et al.
Publicado: (2023)

Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies
por: Pons, Véronique, et al.
Publicado: (2008)

Apolipoprotein E intersects with amyloid-β within neurons
por: Konings, Sabine C, et al.
Publicado: (2023)

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
por: Tamayev, Robert, et al.
Publicado: (2009)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
por: Barrera-Ocampo, Alvaro, et al.
Publicado: (2016)

Crimean-Congo Hemorrhagic Fever Virus Entry into Host Cells Occurs through the Multivesicular Body and Requires ESCRT Regulators
por: Shtanko, Olena, et al.
Publicado: (2014)

Septin6 and Septin7 GTP Binding Proteins Regulate AP-3- and ESCRT-Dependent Multivesicular Body Biogenesis
por: Traikov, Sofia, et al.
Publicado: (2014)

Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe
por: Iwaki, Tomoko, et al.
Publicado: (2007)

Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease
por: Martinsson, Isak, et al.
Publicado: (2022)

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss
por: Lombino, Franco, et al.
Publicado: (2013)

SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein
por: Fjorback, Anja W., et al.
Publicado: (2012)

Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein
por: Chun, Yoon Sun, et al.
Publicado: (2019)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants
por: Mageswaran, Shrawan Kumar, et al.
Publicado: (2015)

Novel Adaptors of Amyloid Precursor Protein Intracellular Domain and Their Functional Implications
por: Chakrabarti, Arunabha, et al.
Publicado: (2012)

Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain
por: Spears, William, et al.
Publicado: (2014)

Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin
por: Stemmer, Nina, et al.
Publicado: (2013)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast
por: Kama, Rachel, et al.
Publicado: (2018)

Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer
por: Zayas‐Santiago, Astrid, et al.
Publicado: (2021)

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
por: Dawkins, Edgar, et al.
Publicado: (2014)

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
por: Saito, Yuhki, et al.
Publicado: (2011)

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
por: De Kimpe, Line, et al.
Publicado: (2012)

Interactions between amyloid, amyloid precursor protein, and mitochondria
por: Wilkins, Heather M.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uqlr481guv0jfr0t7rdq0jglc9