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Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors
The risk of insertional mutagenesis inherent to all integrating exogenous expression cassettes was the impetus for the development of various integration-defective lentiviral vector (IDLV) systems. These systems were successfully employed in a plethora of preclinical applications, underscoring their...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510976/ https://www.ncbi.nlm.nih.gov/pubmed/26229972 http://dx.doi.org/10.1038/mtm.2015.25 |