Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

Phosphofructokinase-1 (PFK1), the “gatekeeper” of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over 10 metabolites and in response to hormonal signaling fine-t...

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Detalles Bibliográficos
Autores principales: Webb, Bradley A., Forouhar, Farhad, Szu, Fu-En, Seetharaman, Jayaraman, Tong, Liang, Barber, Diane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510984/
https://www.ncbi.nlm.nih.gov/pubmed/25985179
http://dx.doi.org/10.1038/nature14405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510984/
https://www.ncbi.nlm.nih.gov/pubmed/25985179
http://dx.doi.org/10.1038/nature14405

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