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Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

Phosphofructokinase-1 (PFK1), the “gatekeeper” of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over 10 metabolites and in response to hormonal signaling fine-t...

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Detalles Bibliográficos
Autores principales:	Webb, Bradley A., Forouhar, Farhad, Szu, Fu-En, Seetharaman, Jayaraman, Tong, Liang, Barber, Diane L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510984/ https://www.ncbi.nlm.nih.gov/pubmed/25985179 http://dx.doi.org/10.1038/nature14405

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