Renal cyst growth is the main determinant for hypertension and concentrating deficit in PKD1-deficient mice

We have bred a Pkd1 floxed allele with a nestin-Cre expressing line to generate cystic mice with preserved GFR to address the pathogenesis of complex ADPKD phenotypes. Hypertension affects about 60% of these patients before loss of renal function, leading to significant morbimortality. Cystic mice w...

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Detalles Bibliográficos
Autores principales: Fonseca, Jonathan M., Bastos, Ana P., Amaral, Andressa G., Sousa, Mauri F., Souza, Leandro E., Malheiros, Denise M., Piontek, Klaus, Irigoyen, Maria C., Watnick, Terry J., Onuchic, Luiz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510986/
https://www.ncbi.nlm.nih.gov/pubmed/24429399
http://dx.doi.org/10.1038/ki.2013.501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510986/
https://www.ncbi.nlm.nih.gov/pubmed/24429399
http://dx.doi.org/10.1038/ki.2013.501

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