Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...

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Detalles Bibliográficos
Autores principales: Abu-Sanad, Atlal, Wang, Yunzhe, Hasheminasab, Fatemeh, Panasci, Justin, Noë, Alycia, Rosca, Lorena, Davidson, David, Amrein, Lilian, Sharif-Askari, Bahram, Aloyz, Raquel, Panasci, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510998/
https://www.ncbi.nlm.nih.gov/pubmed/26257651
http://dx.doi.org/10.3389/fphar.2015.00147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510998/
https://www.ncbi.nlm.nih.gov/pubmed/26257651
http://dx.doi.org/10.3389/fphar.2015.00147

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