Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

The Mst–Lats kinase cascade is central to the Hippo tumor-suppressive pathway that controls organ size and tissue homeostasis. The adaptor protein Mob1 promotes Lats activation by Mst, but the mechanism remains unknown. Here, we show that human Mob1 binds to autophosphorylated docking motifs in acti...

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Detalles Bibliográficos
Autores principales: Ni, Lisheng, Zheng, Yonggang, Hara, Mayuko, Pan, Duojia, Luo, Xuelian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511216/
https://www.ncbi.nlm.nih.gov/pubmed/26108669
http://dx.doi.org/10.1101/gad.264929.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511216/
https://www.ncbi.nlm.nih.gov/pubmed/26108669
http://dx.doi.org/10.1101/gad.264929.115

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