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Novel link between prostaglandin E(2) (PGE(2)) and cholinergic signaling in lung cancer: The role of c-Jun in PGE(2)-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferation

BACKGROUND: Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)) stimulates tumor cell growth and progression. α7 nicotinic acetylcholine receptor (nAChR) is a major mediator of cholinergic signaling in tumor cells. In the present study, we investigated the mechanisms by which PGE(2) increases non-s...

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Detalles Bibliográficos
Autores principales: Zhong, XiaoRong, Fan, Yu, Ritzenthaler, Jeffrey D, Zhang, WenJing, Wang, Ke, Zhou, QingHua, Roman, Jesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511329/
https://www.ncbi.nlm.nih.gov/pubmed/26273406
http://dx.doi.org/10.1111/1759-7714.12219