Cargando…

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

Fibroblast growth factor 21 (FGF21) plays an important role in energy homoeostasis. The unaddressed question of FGF21’s effect on the development and progression of diabetic cardiomyopathy (DCM) is investigated here with FGF21 knockout (FGF21KO) diabetic mice. Type 1 diabetes was induced in both FGF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Xiaoqing, Chen, Jun, Zhang, Chi, Zhou, Shanshan, Zhang, Zhiguo, Chen, Jing, Feng, Wenke, Li, Xiaokun, Tan, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511354/ https://www.ncbi.nlm.nih.gov/pubmed/25823710 http://dx.doi.org/10.1111/jcmm.12530

Ejemplares similares

Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
por: Yan, Xiaoqing, et al.
Publicado: (2015)

Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation
por: Chen, Cui, et al.
Publicado: (2018)

Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy
por: Wei, Xing, et al.
Publicado: (2022)

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
por: Cheng, Peng, et al.
Publicado: (2016)

Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile
por: Lin, Zhuofeng, et al.
Publicado: (2010)

Endogenous FGF1 Deficiency Aggravates Doxorubicin-Induced Hepatotoxicity
por: Gu, Chunjie, et al.
Publicado: (2023)

FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice
por: Zhao, Cuiqing, et al.
Publicado: (2015)

FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling
por: Kong, Yezi, et al.
Publicado: (2022)

Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis
por: Chen, Shenghui, et al.
Publicado: (2020)

SIRT6-specific inhibitor OSS-128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress
por: Huang, Yibo, et al.
Publicado: (2021)

FGF21 and Cardiac Physiopathology
por: Planavila, Anna, et al.
Publicado: (2015)

Localization of FGF21 Protein and Lipid Metabolism-Related Genes in Camels
por: Gao, Yuan, et al.
Publicado: (2023)

Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
por: Athinarayanan, Shaminie, et al.
Publicado: (2020)

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
por: Yang, Chaofeng, et al.
Publicado: (2012)

FGF21 alleviates microvascular damage following limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and anti-oxidative response
por: Chen, Fanfeng, et al.
Publicado: (2022)

FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
por: Yang, Xiaoning, et al.
Publicado: (2022)

Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
por: Wan, Hongzhi, et al.
Publicado: (2019)

Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese
por: Lin, Zhuofeng, et al.
Publicado: (2011)

FGF19 subfamily members: FGF19 and FGF21
por: Dolegowska, Katarzyna, et al.
Publicado: (2019)

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
por: Yang, Hong, et al.
Publicado: (2018)

Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
por: Liu, Yanlong, et al.
Publicado: (2016)

(+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway
por: Xi, Yiyuan, et al.
Publicado: (2021)

Correction for: Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
por: Wan, Hongzhi, et al.
Publicado: (2019)

The role of FGF21 in the pathogenesis of cardiovascular disease
por: Zhang, Ying, et al.
Publicado: (2021)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

The FGF metabolic axis
por: Li, Xiaokun
Publicado: (2019)

Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
por: Zhao, Longwei, et al.
Publicado: (2017)

Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
por: O'Neal, Wesley T., et al.
Publicado: (2014)

Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis
por: Gu, Juan-Juan, et al.
Publicado: (2017)

Analysis of Functional Promoter of Camel FGF21 Gene and Identification of Small Compounds Targeting FGF21 Protein
por: Yong, Fang, et al.
Publicado: (2023)

Association between FGF19, FGF21 and lipocalin-2, and diabetes progression in PCOS
por: Cheng, Feifei, et al.
Publicado: (2021)

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
por: Pereira, Renata O, et al.
Publicado: (2021)

Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation
por: He, Liuqin, et al.
Publicado: (2021)

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
por: Henriksson, Emma, et al.
Publicado: (2020)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
por: Villarroya, Joan, et al.
Publicado: (2018)

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity
por: Tan, Bee K., et al.
Publicado: (2011)

Genetic Engineering of Crypthecodinium cohnii to Increase Growth and Lipid Accumulation
por: Diao, Jinjin, et al.
Publicado: (2018)

Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation
por: Li, Fengyuan, et al.
Publicado: (2021)

FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology
por: Murata, Yusuke, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_asv3237mfc5nat4v3lupa7fnie