Cargando…

The effect of the sphingosine‐1‐phosphate analogue FTY720 on atrioventricular nodal tissue

The sphingosine‐1‐phosphate (S1P) receptor modulator, fingolimod (FTY720), has been used for the treatment of patients with relapsing forms of multiple sclerosis, but atrioventricular (AV) conduction block have been reported in some patients after the first dose. The underlying mechanism of this AV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Egom, Emmanuel E., Kruzliak, Peter, Rotrekl, Vladimir, Lei, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511369/ https://www.ncbi.nlm.nih.gov/pubmed/25864579 http://dx.doi.org/10.1111/jcmm.12549

Ejemplares similares

Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model
por: Moon, Myung-Hee, et al.
Publicado: (2012)

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
por: Takasugi, Nobumasa, et al.
Publicado: (2013)

FTY720, a sphingosine analog, altered placentome histoarchitecture in ewes
por: Dunlap, Kathrin A., et al.
Publicado: (2020)

FTY720-derivatives do not induce FTY720-like lymphopenia
por: Segura-Ulate, Ismael, et al.
Publicado: (2017)

Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers
por: Camp, Sara M., et al.
Publicado: (2020)

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation
por: Ahmed, Naseer, et al.
Publicado: (2017)

The emerging role of FTY720 as a sphingosine 1‐phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms
por: Naseh, Maryam, et al.
Publicado: (2021)

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy
por: Enoru, Julius O., et al.
Publicado: (2016)

Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage
por: Qi, Hui, et al.
Publicado: (2019)

FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology
por: Adachi, Kunitomo, et al.
Publicado: (2007)

Cardioprotective Effects of Sphingosine-1-Phosphate Receptor Immunomodulator FTY720 in a Clinically Relevant Model of Cardioplegic Arrest and Cardiopulmonary Bypass
por: Ahmed, Naseer, et al.
Publicado: (2019)

FTY720 attenuates excitotoxicity and neuroinflammation
por: Cipriani, Raffaela, et al.
Publicado: (2015)

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
por: Tonelli, Francesca, et al.
Publicado: (2010)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth
por: Alshaker, Heba, et al.
Publicado: (2017)

S1P(1) receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine
por: Martínez-Morales, Juan Carlos, et al.
Publicado: (2018)

Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720
por: Roggeri, Alessandra, et al.
Publicado: (2023)

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
por: Patmanathan, Sathya Narayanan, et al.
Publicado: (2015)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

Fingolimod (Gileyna, FTY720): Innovative treatment for multiple sclerosis
por: Pinki,, et al.
Publicado: (2011)

Antinociceptive activity of the S1P-receptor agonist FTY720
por: Coste, Ovidiu, et al.
Publicado: (2008)

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages
por: Tachibana, Koki, et al.
Publicado: (2022)

Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy
por: Sun, Rui-zhen, et al.
Publicado: (2018)

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model
por: Ahmed, Naseer, et al.
Publicado: (2020)

Actions of FTY720 (Fingolimod), a Sphingosine-1-Phosphate Receptor Modulator, on Delayed-Rectifier K(+) Current and Intermediate-Conductance Ca(2+)-Activated K(+) Channel in Jurkat T-Lymphocytes
por: Chang, Wei-Ting, et al.
Publicado: (2020)

Development and Effects of FTY720 Ophthalmic Solution on Corneal Allograft Survival
por: Liu, Zhaochuan, et al.
Publicado: (2015)

Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
por: Xu, Hao-Liang, et al.
Publicado: (2015)

Fingolimod (FTY720): First approved oral therapy for multiple sclerosis
por: Sharma, Sushil, et al.
Publicado: (2011)

Lymphocyte Modulation with FTY720 Improves Hemorrhagic Shock Survival in Swine
por: Hawksworth, Jason S., et al.
Publicado: (2012)

FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value
por: Thomson, Andrew
Publicado: (2006)

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage
por: Stradner, Martin H, et al.
Publicado: (2011)

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
por: Blanc, Caroline A, et al.
Publicado: (2014)

FTY720 restores endothelial cell permeability induced by malaria sera
por: Oggungwan, Karanyaporn, et al.
Publicado: (2018)

FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways
por: Lange, Ingo, et al.
Publicado: (2017)

Effect of FTY720P on lipid accumulation in HEPG2 cells
por: Rida, Reem, et al.
Publicado: (2023)

FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning
por: Vessey, Donald A., et al.
Publicado: (2013)

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
por: Saddoughi, Sahar A, et al.
Publicado: (2013)

A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models
por: Vidal-Martinez, Guadalupe, et al.
Publicado: (2020)

FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
por: Yu, Hong, et al.
Publicado: (2015)

FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity
por: Ahmed, Dilruba, et al.
Publicado: (2015)

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
por: Wu, Celina, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ofgj0m86ip3cb4soivatp2p2eg