Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-type HDACi, has proved to be a promising cure in clin...

Descripción completa

Detalles Bibliográficos
Autores principales: Valiuliene, Giedre, Stirblyte, Ieva, Cicenaite, Dovile, Kaupinis, Algirdas, Valius, Mindaugas, Navakauskiene, Ruta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511371/
https://www.ncbi.nlm.nih.gov/pubmed/25864732
http://dx.doi.org/10.1111/jcmm.12550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511371/
https://www.ncbi.nlm.nih.gov/pubmed/25864732
http://dx.doi.org/10.1111/jcmm.12550

Ejemplares similares