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Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-type HDACi, has proved to be a promising cure in clin...

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Detalles Bibliográficos
Autores principales:	Valiuliene, Giedre, Stirblyte, Ieva, Cicenaite, Dovile, Kaupinis, Algirdas, Valius, Mindaugas, Navakauskiene, Ruta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511371/ https://www.ncbi.nlm.nih.gov/pubmed/25864732 http://dx.doi.org/10.1111/jcmm.12550

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