Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines

The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration. Here, we performed cell-based screening of a collection of natural products an...

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Detalles Bibliográficos
Autores principales: Seo, Yohan, Park, Jinhong, Kim, Minseo, Lee, Ho K., Kim, Jin-Hee, Jeong, Jin-Hyun, Namkung, Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511415/
https://www.ncbi.nlm.nih.gov/pubmed/26196390
http://dx.doi.org/10.1371/journal.pone.0133656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511415/
https://www.ncbi.nlm.nih.gov/pubmed/26196390
http://dx.doi.org/10.1371/journal.pone.0133656

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